Developments in tandem ion mobility mass spectrometry

Ion Mobility Mass Spectrometry

for more complex analysers for automated sample processing and plant control. The separation time will continue to decrease; in the past there has been limited interest in fast separations but this could change as automated sample processing is developed. Increasing use of coupled techniques such as GC-GC, liquid chromatography-GC, and supercritical Suid chromatography-GC for the separation of ...

Ion Mobility-Mass Spectrometry

Selected Tandem Mass Spectrometry Ion

1 Selected tandem mass spectrometry (MS/MS) ion monitoring (SMIM) is the most 2 suitable scanning mode to detect known peptides in complex samples when an ion-trap 3 mass spectrometer is the instrument used for the analysis. In this mode, the MS detector 4 is programmed to perform continuous MS/MS scans on one or more selected 5 precursors, either during a selected time interval, or along the w...

Differential Ion Mobility Spectrometry Coupled to Tandem Mass Spectrometry Enables Targeted Leukemia Antigen Detection

Differential ion mobility spectrometry (DIMS) can be used as a filter to remove undesired background ions from reaching the mass spectrometer. The ability to use DIMS as a filter for known analytes makes DIMS coupled to tandem mass spectrometry (DIMS-MS/MS) a promising technique for the detection of cancer antigens that can be predicted by computational algorithms. In experiments using DIMS-MS/...

Tandem ion mobility-mass spectrometry (IMS-MS) study of ion evaporation from ionic liquid-acetonitrile nanodrops.

Ion evaporation is an essential step in the formation of charged ions from electrosprays, yet many aspects of the process are poorly understood. The ion evaporation kinetics of the 1-ethyl-3-methyl-imidazolium+ (EMI+) based ionic liquids (ILs) EMI-BF4, EMI-bis(perfluoroethylsulfonyl)imide, EMI-bis(trifluoromethylsulfonyl)imide and EMI-tris(trifluoromethylsulfonyl)methide (EMI-Methide) are studi...